Model driven design of particulate products and processes

Our knowledge of the underlying physics of particulate processes – those that make particles or form them into structured products - has increased substantially over the last two decades.  New commercial software tools are available for process modelling using macroscopic models (population balances) and particle scale simulations (eg. DEM simulations).  However, these modeling approaches have still to gain strong traction in industry.  This presentation will consider a model driven design approach using twin screw wet granulation (TSG).  A macroscopic model for TSG is developed based on a mechanistic understanding the process.  A methodology for coupling this model with DEM simulations is described, and validation of the model using experimental data from a Consigma 1 TSG for a model pharmaceutical formulation is presented.  A workflow for transfer of the model and its use in industry is described.  In continuous pharmaceutical manufacture, TSG is an intermediate step providing granules as the feed for the tablet press.  The opportunities created by better control of granule attributes for the tableting process are discussed.

Jim Litster is Professor and Head of the Chemical and Biological Engineering Department at the University of Sheffield, following previous academic appointments at Purdue University (2007-2015) and The University of Queensland (1987-2007). His research area is Particulate Products and Processes.  His research focuses on production of particles and particulate delivery forms with well controlled size and morphology from sub-micron to millimeter scale using processes such as wet granulation, crystallization and spherical agglomeration. He is an international leading expert on wet granulation with over 30 years experience in the field. Jim is a Fellow of the Australian Academy of Technological Sciences and Engineering. He has received several awards internationally for his work, most recently the Geldart Medal on Particle Technology from the Institution of Chemical Engineers in 2017.